Question: What Is Normal Range For IgM?

What are normal IgM levels?

The manufacturer indicates the following reference intervals for healthy adults: IgA 70–400 mg/dl, IgG 700–1600 mg/dl and IgM 40–230 mg/dl [35]..

What causes high IgM levels?

If your immunoglobulin level is high, it might be caused by: Allergies. Chronic infections. An autoimmune disorder that makes your immune system overreact, such as rheumatoid arthritis, lupus, or celiac disease.

Where is IgM found in the body?

IgM antibodies are the largest antibody. They are found in blood and lymph fluid and are the first type of antibody made in response to an infection. They also cause other immune system cells to destroy foreign substances. IgM antibodies are about 5% to 10% of all the antibodies in the body.

What is a low IgM level?

Could this be a selective IgM deficiency? Selective IgM deficiency is an isolated absence or profound deficiency of serum IgM associated with infections, atopic manifestations, autoimmunity, or malignant conditions. Serum IgM levels are less than 10–15 mg/dl in infants and children and less than 20–30 mg/dl in adults.

Is High IgM serious?

Patients with hyper IgM are at significant risk for opportunistic and repeated infections. In addition, the defect in the immune system results in a decreased ability to identify and fight cancer cells as well as an inability to produce a response to pathogens.

Which comes first IgG or IgM?

IgM antibody appears first, followed by IgA on mucosal surfaces or IgG in the serum. The IgG antibody is the major antibody of the response and is very stable, with a half-life of 7 to 21 days.

What is the function of IgM?

IgM is present on B cells and its main function apparently is the control of B-cell activation. B-cells create IgM antibodies as a first line of defense. Their large size gives them excellent binding avidity, and can pick up trace amounts of infection to mark for recognition by phagocytes.

What is a high IgM?

Patients with Hyper-IgM (HIGM) syndrome are susceptible to recurrent and severe infections and in some types of HIGM syndrome opportunistic infections and an increased risk of cancer as well. The disease is characterized by decreased levels of immunoglobulin G (IgG) in the blood and normal or elevated levels of IgM.

What does IgM stand for?

Immunoglobulin M (IgM), which is found mainly in the blood and lymph fluid, is the first antibody to be made by the body to fight a new infection. Immunoglobulin E (IgE), which is associated mainly with allergic reactions (when the immune system overreacts to environmental antigens such as pollen or pet dander).

What is IgM quantitative?

Quantitative serum immunoglobulin tests are used to detect abnormal levels of the three major classes (IgG, IgA and IgM). Testing is used to help diagnose various conditions and diseases that affect the levels of one or more of these immunoglobulin classes.

What does an IgM blood test show?

Immunoglobulin M (IgM): Found mainly in blood and lymph fluid, this is the first antibody the body makes when it fights a new infection. Immunoglobulin E (IgE): Normally found in small amounts in the blood. There may be higher amounts when the body overreacts to allergens or is fighting an infection from a parasite.

Is IgM deficiency serious?

Selective IgM deficiency is more common than previously recognized and is likely a heterogeneous disorder. Patients with SIGMD may be asymptomatic; however, commonly present with chronic and recurrent infections; some of them could be serious and life threatening.

What happens if immunoglobulin is high?

If your immunoglobulin levels are too high, it may be a sign of an autoimmune disease, a chronic illness, an infection, or a type of cancer. Symptoms of these conditions vary greatly.

What is the treatment for low IgM?

Treatment options depend on the severity of symptoms and whether a person has an associated underlying disease. Treatment may include prompt treatment of infections, taking measures to prevent infections, prophylactic antibiotics , and immune globulin therapy.

How do you treat low immunoglobulins?

Currently, the accepted therapy for IgG deficiency is the intravenous administration of 300-600 mg/kg of IgG once every 3-4 weeks, or 100-200 mg/kg/wk subcutaneously. Higher doses have been shown to be more effective in reducing infections in patients with histories of chronic or recurrent sinopulmonary infections.